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34 |
BRS Physiology |
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Signaling Pathways and Mechanisms for Autonomic Receptors |
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t a b l e |
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2.2 |
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Receptor |
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Location |
G Protein |
Mechanism |
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Adrenergic |
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α1 |
Smooth muscle |
Gq |
α2 |
Gastrointestinal tract |
Gi |
β1 |
Heart |
Gs |
β2 |
Smooth muscle |
Gs |
Cholinergic |
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↑IP3 /Ca2+ ↓ cAMP
↑cAMP
↑cAMP
NM (N1) |
Skeletal muscle |
— |
NN (N2) |
Autonomic ganglia |
— |
M1 |
CNS |
Gq |
M2 |
Heart |
Gi |
M3 |
Glands, smooth muscle |
Gq |
Opening Na+/K+ channels Opening Na+/K+ channels
↑IP3 /Ca2+ ↓ cAMP
↑IP3 /Ca2+
IP3 = inositol 1,4,5-triphosphate; cAMP = cyclic adenosine monophosphate.
C.Receptor types in the ANS (Table 2.2)
1. Adrenergic receptors (adrenoreceptors) a. a1 Receptors
■are located on vascular smooth muscle of the skin and splanchnic regions, the gastrointestinal (GI) and bladder sphincters, and the radial muscle of the iris.
■produce excitation (e.g., contraction or constriction).
■are equally sensitive to norepinephrine and epinephrine. However, only norepi-
nephrine released from adrenergic neurons is present in high enough concentrations to activate α1 receptors.
■Mechanism of action: Gq protein, stimulation of phospholipase C and increase in inositol 1,4,5-triphosphate (IP3) and intracellular [Ca2+].
b. a2 Receptors
■are located on sympathetic postganglionic nerve terminals (autoreceptors), platelets, fat cells, and the walls of the GI tract (heteroreceptors).
■often produce inhibition (e.g., relaxation or dilation).
■Mechanism of action: Gi protein, inhibition of adenylate cyclase and decrease in cyclic adenosine monophosphate (cAMP).
c. b1 Receptors
■are located in the sinoatrial (SA) node, atrioventricular (AV) node, and ventricular muscle of the heart.
■produce excitation (e.g., increased heart rate, increased conduction velocity, increased contractility).
■are sensitive to both norepinephrine and epinephrine, and are more sensitive than the α1 receptors.
■Mechanism of action: Gs protein, stimulation of adenylate cyclase and increase in cAMP.
d. b2 Receptors
■are located on vascular smooth muscle of skeletal muscle, bronchial smooth muscle, and in the walls of the GI tract and bladder.
■produce relaxation (e.g., dilation of vascular smooth muscle, dilation of bronchioles, relaxation of the bladder wall).
■are more sensitive to epinephrine than to norepinephrine.
■are more sensitive to epinephrine than the α1 receptors.
■Mechanism of action: same as for β1 receptors.
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Neurophysiology |
35 |
Chapter 2 |
2. Cholinergic receptors (cholinoreceptors) a. Nicotinic receptors
■are located in the autonomic ganglia (NN) of the sympathetic and parasympathetic nervous systems, at the neuromuscular junction (NM), and in the adrenal medulla (NN). The receptors at these locations are similar, but not identical.
■are activated by ACh or nicotine.
■produce excitation.
■are blocked by ganglionic blockers (e.g., hexamethonium) in the autonomic ganglia, but not at the neuromuscular junction.
■Mechanism of action: ACh binds to α subunits of the nicotinic ACh receptor. The nicotinic ACh receptors are also ion channels for Na+ and K+.
b. Muscarinic receptors
■are located in the heart (M2), smooth muscle (M3), and glands (M3).
■are inhibitory in the heart (e.g., decreased heart rate, decreased conduction velocity in AV node).
■are excitatory in smooth muscle and glands (e.g., increased GI motility, increased secretion).
■are activated by ACh and muscarine.
■are blocked by atropine.
■Mechanism of action:
(1) Heart SA node: Gi protein, inhibition of adenylate cyclase, which leads to opening of K+ channels, slowing of the rate of spontaneous Phase 4 depolarization, and
decreased heart rate.
(2) Smooth muscle and glands: Gq protein, stimulation of phospholipase C, and increase in IP3 and intracellular [Ca2+].
3. Drugs that act on the ANS (Table 2.3)
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t a b l e |
2.3 |
Prototypes of Drugs that Affect Autonomic Activity |
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Type of Receptor |
Agonist |
Antagonist |
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Adrenergic |
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α1 |
Norepinephrine |
Phenoxybenzamine |
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Phenylephrine |
Phentolamine |
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Prazosin |
α2 |
Clonidine |
Yohimbine |
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β1 |
Norepinephrine |
Propranolol |
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Isoproterenol |
Metoprolol |
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Dobutamine |
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β2 |
Isoproterenol |
Propranolol |
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Albuterol |
Butoxamine |
Cholinergic |
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Nicotinic |
ACh |
Curare (neuromuscular |
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Nicotine |
junction N1 |
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Carbachol |
receptors) |
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Hexamethonium (ganglionic |
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N2 receptors) |
Muscarinic |
ACh |
Atropine |
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Muscarine |
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Carbachol |
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ACh = acetylcholine.
36 |
Brs Physiology |
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t a b l e |
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2.4 |
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Effect of the Autonomic Nervous System on Organ Systems |
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sympathetic |
sympathetic |
Parasympathetic |
Parasympathetic |
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organ |
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Action |
receptor |
Action |
receptor |
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Heart |
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↑ heart rate |
β |
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↓ heart rate |
M |
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↑ contractility |
β1 |
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↓ contractility (atria) |
M2 |
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↑ AV node conduction |
β11 |
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↓ AV node conduction |
M22 |
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Vascular smooth |
Constricts blood |
α1 |
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— |
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muscle |
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vessels in skin; |
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splanchnic |
β2 |
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— |
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Dilates blood vessels |
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in skeletal muscle |
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Gastrointestinal tract |
↓ motility |
α |
, β |
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↑ motility |
M |
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Constricts sphincters |
α12 |
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Relaxes sphincters |
M33 |
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Bronchioles |
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Dilates bronchiolar |
β2 |
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Constricts bronchiolar |
M3 |
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smooth muscle |
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smooth muscle |
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Male sex organs |
Ejaculation |
α |
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Erection |
M |
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Bladder |
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Relaxes bladder wall |
β |
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Contracts bladder wall |
M |
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Constricts sphincter |
α21 |
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Relaxes sphincter |
M33 |
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Sweat glands |
↑ sweating |
M (sympathetic |
— |
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cholinergic) |
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Eye |
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α1 |
Radial muscle, iris |
Dilates pupil (mydriasis) |
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Circular sphincter |
— |
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muscle, iris |
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β |
Ciliary muscle |
Dilates (far vision) |
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Kidney |
↑ renin secretion |
β1 |
— |
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Constricts pupil (miosis) |
M |
Contracts (near vision) |
M |
— |
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Fat cells |
↑ lipolysis |
β1 |
— |
AV = atrioventricular; M = muscarinic.
D. effects of the Ans on various organ systems (table 2.4)
e.Autonomic centers—brain stem and hypothalamus
1.medulla
■Vasomotor center
■Respiratory center
■Swallowing, coughing, and vomiting centers
2.Pons
■Pneumotaxic center
3.midbrain
■Micturition center
4.Hypothalamus
■Temperature regulation center
■Thirst and food intake regulatory centers
II. sensory systems
A.sensory receptors—general
■are specialized epithelial cells or neurons that transduce environmental signals into neural signals.
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Neurophysiology |
37 |
Chapter 2 |
■The environmental signals that can be detected include mechanical force, light, sound, chemicals, and temperature.
1. Types of sensory transducers a. Mechanoreceptors
■Pacinian corpuscles
■Joint receptors
■Stretch receptors in muscle
■Hair cells in auditory and vestibular systems
■Baroreceptors in carotid sinus
b. Photoreceptors
■Rods and cones of the retina c. Chemoreceptors
■Olfactory receptors
■Taste receptors
■Osmoreceptors
■Carotid body O2 receptors
d. Extremes of temperature and pain
■ Nociceptors
2. Fiber types and conduction velocity (Table 2.5)
3. Receptive field
■is an area of the body that, when stimulated, changes the firing rate of a sensory neuron. If the firing rate of the sensory neuron is increased, the receptive field is excitatory. If the firing rate of the sensory neuron is decreased, the receptive field is inhibitory.
4. Steps in sensory transduction
a. Stimulus arrives at the sensory receptor. The stimulus may be a photon of light on the retina, a molecule of NaCl on the tongue, a depression of the skin, and so forth.
b. Ion channels are opened in the sensory receptor, allowing current to flow.
t a b l e 2.5 Characteristics of Nerve Fiber Types
General Fiber Type |
Sensory Fiber Type |
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Conduction |
and Example |
and Example |
Diameter |
Velocity |
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A-alpha |
Ia |
Largest |
Fastest |
Large α-motoneurons |
Muscle spindle afferents |
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Ib |
Largest |
Fastest |
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Golgi tendon organs |
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A-beta |
II |
Medium |
Medium |
Touch, pressure |
Secondary afferents of muscle |
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spindles; touch and pressure |
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A-gamma |
— |
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γ-Motoneurons to muscle spindles |
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Medium |
Medium |
(intrafusal fibers) |
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A-delta |
III |
Small |
Medium |
Touch, pressure, temperature, |
Touch, pressure, fast pain, |
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and pain |
and temperature |
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B |
— |
Small |
Medium |
Preganglionic autonomic fibers |
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C |
IV |
Smallest |
Slowest |
Slow pain; postganglionic autonomic fibers |
Pain and temperature (unmyelinated) |
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