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©2013 Kaplan, Inc.
Allrights reserved. No part of this book may be reproduced in any form, by photostat, microfilm, xerography or any other means, or incorporated into any information retrieval system, electronic or mechanical, without the written permission of Kaplan, Inc.
Not for resale.
Authors
James White, Ph.D.
Assistant Professor of Cell Biology
School of Osteopathic Medicine
University of Medicine and Dentistry of New Jersey
Stratford, NJ
Adjunct Assistant Professor of Cell and Developmental Biology
University of Pennsylvania School of Medicine
Philadelphia, PA
David Seiden, Ph.D.
Professor of Neuroscience and Cell Biology
Senior Academic Advisor to the Dean
Rutgers-Robert Wood Johnson Medical School
Piscataway, NJ
Contents
Preface . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . vii
Section I: Histology and Cell Biology |
|
Chapter 1: Cell Biology and Epithelia .......................... |
3 |
Chapter 2: Connective Tissue ............................... |
27 |
Chapter 3: Cartilage and Bone .............................. |
35 |
Chapter4: Muscle Tissue................................... |
45 |
Chapters: Nervous Tissue.................................. |
55 |
Chapter 6: Immune Tissues................................. |
65 |
Chapter 7: Respiratory System .............................. |
77 |
Chapter 8: Gastrointestinal System........................... |
87 |
Chapter 9: Urinary System.................................. |
115 |
Chapter 10: Male Reproductive System ...................... |
125 |
Chapter 11: Female Reproductive System .................... |
139 |
Chapter 12: Integument................................... |
149 |
Section11: Early Embryology |
|
Chapter 1: Gonad Development............................ |
155 |
Chapter 2: Week 1: Beginning of Development................. |
161 |
Chapter 3: Week 2: Formation of the Bilaminar Embryo ........ |
163 |
Chapter 4: Embryonic Period (Weeks 3-8) ................... |
165 |
MEDICAL
V
Section Ill: Gross Anatomy
Chapter 1: Back and Autonomic Nervous System . . . . . . . . . . . . . . . 171
Chapter 2: Thorax.. . . ... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 185
Chapter 3: Abdomen, Pelvis, and Perineum. . . . ... . . .. . ....... |
231 |
Chapter 4: Upper Limb . . .. . . ... . . .. . . . . . . . . . . . . . . . . . . . . . . |
285 |
Chapter 5: Lower Limb . . . .. . . . ... . .. . . . .. . . . . . . . . . . . . . . . . |
301 |
Chapter 6: Head and Neck . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . |
. 313 |
Section IV: Neuroscience |
|
Chapter 1: Nervous System . .. . . .. . . . . . . . . . . . . . . . . . . . . . . ... |
333 |
Chapter 2: Central Nervous System . . . . . .. . . . . . . . . . . . . . . . . . . |
345 |
Chapter3: Ventricular System . ............................. |
351 |
Chapter4: The Spinal Cord................................ |
357 |
Chapter 5: The Brain Stem. . . . . . .. . . . ... . . . . . .. . . . . . . . . . . . . |
383 |
Chapter 6: The Cerebellum . . . . . . . . . . . . . . . .. . . . ... . . . . . . . . . |
421 |
Chapter 7: Basal Ganglia. . . . . . . . . . . . . . . . . .. . . . . .. . . . . . . . . . |
429 |
Chapter 8: Visual Pathways . . . . . . . . . . . .. . . . . . . . . . . . . . . .. . . . |
437 |
Chapter 9: Diencephalon. . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . |
447 |
Chapter 10: Cerebral Cortex . . .. . . . .. . . ... . . . .. . . . ... . . . . . . |
455 |
Chapter 11: Limbic System . ........... . ................... |
475 |
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . |
481 |
Vi MEDICAL
Preface
These 7 volumes of Lecture Notes represent the most-likely-to-be-tested material on the current USMLE Step 1 exam. Please note that these are Lecture Notes, not review books. The Notes were designed to be accompanied by faculty lectures live, on video, or on the web. Reading them without accessing the accompanying lectures is not an effective way to review for the USMLE.
To maximize the effectiveness of these Notes, annotate them as you listen to lec tures. To facilitate this process, we've created wide, blank margins. While these margins are occasionally punctuated by faculty high-yield "margin notes:' they are, for the most part, left blank for your notations.
Many students find that previewing the Notes prior to the lecture is a very effec tive way to prepare for class. This allows you to anticipate the areas where you'll need to pay particular attention. It also affords you the opportunity to map out how the information is going to be presented and what sort of study aids (charts, diagrams, etc.) you might want to add. This strategy works regardless of whether you're attending a live lecture or watching one on video or the web.
Finally, we want to hear what you think. What do you like about the Notes? What could be improved? Please share your feedback by e-mailing us at medfeedback@ kaplan.com.
Thank you for joining Kaplan Medical, and best of luck on your Step 1 exam!
Kaplan Medical
MEDICAL |
Vii |
SECTION
Histology and
Cell Biology
Cell Biology and Epithelia |
1 |
NUCLEUS
The nucleus (Figure 1-1-1) is the site of deoxyribonucleic acid (DNA) replication and transcription of DNA into precursor ribonucleic acid (RNA) molecules. It contains allof the enzymes required for replication and repair of newly synthe sized DNA, as well as for transcription and processing of precursor RNA mol ecules. It is enclosed by the nuclear envelope and contains the nuclear lamina, nucleolus, and chromatin.
Euchromatin
Heterochromatin
Nucleolus
Figure 1-1-1. Nucleus
Nuclear Envelope
The nuclear envelope is a double membrane containing pores that are approxi mately 90 nm in diameter. The outer nuclear membrane is continuous with the endoplasmic reticulum.
Nuclear Lamina
The nuclear lamina is a latticelike network of proteins that include lamins. Lam ins attach chromatin to the inner membrane of the nuclear envelope and partici pate in the breakdown and reformation of the nuclear envelope during the cell cycle.
mitosis initiates nuclear disassembly into smallvesicles.
MEDICAL 3
Section I • Histology and Cell Biology
Nucleolus
The nucleolus is responsible for ribosomal RNA (rRNA) synthesis and ribosome assembly. It contains 3 morphologically distinct zones:
•Granular zone-found at the periphery; contains ribosomal precursor particles in various stages of assembly.
•Fibrillar zone-centrally located; contains ribonuclear protein fibrils.
•Fibrillar center-containsDNA that is not being transcribed.
Chromatin
Chromatin is a complex of DNA, histone proteins, and nonhistone proteins.
•DNA-a double-stranded helical molecule that carries the genetic infor mation of the cell. It exists in 3 conformations: B DNA, ZDNA, and ADNA.
•Histone proteins-positively charged proteins enriched with lysine and arginine residues. They are important in forming 2 types of structures in chromatin: nucleosomes and solenoid fibers. The nucleosomesare the basic repeating units of the chromatin fiber, having a diameter of approximately 10 nm.
•Nonhistone proteins-include enzymes involved in nuclear functions such as replication, transcription, DNA repair, and regulation of chro matin function. They are acidic or neutral proteins.
Forms ofchromatin
•Heterochromatin-highly condensed (30-nm solenoid fibers or higher states of condensation) and transcriptionally inactive. In a typical eukaryotic cell, approximately 10% of the chromatin is heterochro matin. Almost the entire inactive X chromosome (Barr body) in each somatic cell in a woman is condensed into heterochromatin.
•Euchromatin-a more extended form ofDNA, which is potentially transcriptionally active. In a typical cell, euchromatin accounts for approximately 90% of the total chromatin, although only about 10% is being actively transcribed in the 10-nm fiber of nucleosomes.
CYTOPLASM
Ribosomes
Ribosomes are composed of rRNA and protein. They consist of large (605) and small (405) subunits. Ribosomes are assembled in the nucleus and transported to the cytoplasm through the nuclear pores. The large ribosomal subunits are synthesized in the nucleolus, whereas the small subunits are syn thesized in the nucleus.
• Polysomes-Ribosomes often form polysomes, which consist of a single messenger RNA (mRNA) that is being translated by several ribosomes at the same time. The ribosomes move on the mRNA from the 5' end toward the 3' end. The 2 ribosomal subunits associate on the mRNA, with the small subunit binding first.
4MEDICAL
Section I • Histology and Cell Biology
Endoplasmic Reticulum
The endoplasmic reticulum exists in 2 forms, rough endoplasmic reticulum
(RER) and smooth endoplasmic reticulum (SER).
Rough endoplasmic reticulum
•RER is a single, lipid bilayer continuous with the outer nuclear mem brane. It is organized into stacks oflarge flattened sacs called cisternae that are studded with ribosomes on the cytoplasmic side (Figure I-1-3).
•RER synthesizes proteins that are destined for the Golgi apparatus, secretion, the plasma membrane, and lysosomes. RER is very promi nent in cells that are specialized in the synthesis of proteins destined for secretion (e.g., pancreatic acinar cells).
Figure 1-1-3. Rough endoplasmic reticulum
Smooth endoplasmic reticulum
•SER is a network of membranous sacs, vesicles, and tubules continuous with the RER, but lacking ribosomes (Figure 1-1-4).
•SER contains enzymes involved in the bioynthesis of phospholipids, triglycerides, and sterols.
6MEDICAL
Chapter i.
;
Copyright Lippincott Williams & Wilkins. Used with permission.
Figure 1-1-4. Human corpus luteum of pregnancy
Functions ofSER
Detoxification Reactions
These are reactions that make compounds water-soluble so that they can be excreted. Two types of reactions that increase solubility are:
•Hydroxylation reactions-by way of hydroxylase complexes containing cytochrome P450, a flavoprotein, and a nonheme iron protein
•Conjugation reactions-the transfer of polar groups (i.e., glucuronic
acid) from the active carrier UDP-glucuronic acid to the toxic water insoluble molecule
Steroid Synthesis
Glycogen Degradation and Gluconeogenesis
Removal of the phosphate group from glucose-6-phosphate by the enzyme glu cose-6 phosphatase, an integral membrane protein of the SER. This controls the formation of free glucose from glycogen and via gluconeogenesis.
Reactions in Lipid Metabolism
Lipolysis begins in the SER with the release of a fatty acid from triglyceride. The SER is also the site where lipoprotein particles are assembled.
Sequestration and Release of Calcium Ions
In striated muscle the SER is known as the sarcoplasmic reticulum (SR). The sequestration and release of calcium ions takes place in the SR.
• Cell Biology and Epithelia
MEDICAL 7